Define forward and reverse genetics. 2What gene is associated with the “cul-de-sac” allele?

| April 14, 2018


Define forward and reverse genetics. 

2What gene is associated with the “cul-de-sac” allele?  How is it similar to the one reported by Potter et al?  

3Describe the cul-de-sac mutation in relation to Mutation Type and Amino Acid Change 

4.The video you just viewed is of a G3 mouse, explain what this means. 

5.Explain why “Whole exome HiSeq sequencing of the G1 grandsire identified 57 mutations”. 

6.Provide the gene symbol, full name of the gene, the mouse chromosome to which it maps and the RefSeq mRNA accession number (the one that encodes the longest isoform). 

7.Explain the role of RISC in RNA interferance 

8To demonstrate you have completed this task correctly, paste the top RNAi sequence below. 

9.In your own words, briefly explain the CRISPR-Cas9 method of gene perturbation 

10To demonstrate you have completed this task correctly, paste the top sgRNA sequence below. 

11.Why is the massively parallel reporter assay (MPRA) important to understanding common human diseases? 

12Which allele is associated with ankylosing spondylitis and how does it affect the expression of PTGER4? 

13.What can you predict about Craig Venter’s expression levels of PTGER4 

14In your own words, describe your understanding of systems biology.  Include the techniques used and examples of mathematical models 

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